Bioactive Polyetheretherketone with Gelatin Hydrogel Leads to Sustained Release of Bone Morphogenetic Protein-2 and Promotes Osteogenic Differentiation

Polyetheretherketone (PEEK) is one of the most promising implant materials for hard tissues due to its similar elastic modulus; however, usage PEEK still limited owing biological inertness and low osteoconductivity. The objective study was provide with ability sustain release growth factors osteogenic differentiation stem cells. surface sandblasted modified polydopamine (PDA). Moreover, successful sandblasting PDA modification confirmed through physicochemical characterization. gelatin hydrogel then chemically bound by adding a solution glutaraldehyde PDA-modified PEEK. binding degradation (GPEEK) were confirmed, GPEEK mineralization observed in simulated body fluid. Sustained bone morphogenetic protein (BMP)-2 GPEEK. When cultured on BMP-2, human mesenchymal cells (hMSCs) exhibited differentiation. We conclude that incorporating BMP-2 substrate tissue engineering.